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Effect of various antioxidants and their combinations on bull semen cryopreservation

The build-up of ROS induces ER stress, causing the release of damage-associated molecular patterns (DAMPs) like calreticulin, ATP and high mobility group box 1 [261, 262]

While IGF-1 has insulin-agonistic actions and has been used for treatment of severe insulin resistance, IGF-1 reduction with the GH antagonist pegvisomant improves glycemic control in acromegalic patients with diabetes or impaired glucose tolerance despite elevated GH (35, 36)

Novo initially dominated the GLP-1 market, but Lilly has overtaken it with more effective drugs